Reaction-Difusion Model of Early Carcinogenesis: The Effects of Influx of Mutated Cells
Anna Marciniak-Czochra, Marek Kimmel (2008)
Mathematical Modelling of Natural Phenomena
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In this paper we explore a new model of field carcinogenesis, inspired by lung cancer precursor lesions, which includes dynamics of a spatially distributed population of pre-cancerous cells , constantly supplied by an influx of mutated normal cells. Cell proliferation is controlled by growth factor molecules bound to cells, . Free growth factor molecules are produced by precancerous cells and may diffuse before they become bound to other cells. The purpose of modelling is to investigate...