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Free Boundary Problems Associated with Multiscale Tumor Models

A. Friedman — 2009

Mathematical Modelling of Natural Phenomena

The present paper introduces a tumor model with two time scales, the time during which the tumor grows and the cycle time of individual cells. The model also includes the effects of gene mutations on the population density of the tumor cells. The model is formulated as a free boundary problem for a coupled system of elliptic, parabolic and hyperbolic equations within the tumor region, with nonlinear and nonlocal terms. Existence and uniqueness theorems are proved, and properties of the free boundary...

Cancer as Multifaceted Disease

A. Friedman — 2012

Mathematical Modelling of Natural Phenomena

Cancer has recently overtaken heart disease as the world’s biggest killer. Cancer is initiated by gene mutations that result in local proliferation of abnormal cells and their migration to other parts of the human body, a process called metastasis. The metastasized cancer cells then interfere with the normal functions of the body, eventually leading to death. There are two hundred types of cancer, classified by their point of origin. Most of them...

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