Resonance and anti-resonance in the design of chemotherapeutic protocols.
Analysis of a Mathematical Model for the Molecular Mechanism of Fate Decision in Mammary Stem Cells
Recently, adult stem cells have become a focus of intensive biomedical research, but the complex regulation that allows a small population of stem cells to replenish depleted tissues is still unknown. It has been suggested that specific tissue structures delimit the spaces where stem cells undergo unlimited proliferation (). In contrast, mathematical analysis suggests that a feedback control of stem cells on their own proliferation and differentiation (denoted ) suffices for preserving homeostasis...
Intensified Doxorubicin-Based Regimen Efficacy in Residual Non-Hodgkin's Lymphoma Disease: Towards a Computationally Supported Treatment Improvement
Despite recent advances, treatment of patients with aggressive Non-Hodgkin's lymphoma (NHL) has yet to be optimally designed. Notwithstanding the contribution of molecular treatments, intensification of chemotherapeutic regimens may still be beneficial. Hoping to aid in the design of intensified chemotherapy, we put forward a mathematical and computational model that analyses the effect of Doxorubicin on NHL over a wide range of patho-physiological conditions. The model represents tumour growth...
Improving Cancer Therapy by Doxorubicin and Granulocyte Colony-Stimulating Factor: Insights from a Computerized Model of Human Granulopoiesis
Neutropenia is a significant dose-limiting toxicity of cancer chemotherapy, especially in dose-intensified regimens. It is widely treated by injections of Granulocyte Colony-Stimulating Factor (G-CSF). However, optimal schedules of G-CSF administration are still not determined. In order to aid in identifying more efficacious and less neutropenic treatment protocols, we studied a detailed physiologically-based computer model of granulopoiesis, as affected by different treatment schedules of doxorubicin...
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