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Let $ℛ$ be a semiprime ring with unity $e$ and $\phi$, $\varphi$ be automorphisms of $ℛ$. In this paper it is shown that if $ℛ$ satisfies $$2𝒟\left(x^n\right)=𝒟\left(x^{n-1}\right)\phi \left(x\right)+\varphi \left(x^{n-1}\right)𝒟\left(x\right)+𝒟\left(x\right)\phi \left(x^{n-1}\right)+\varphi \left(x\right)𝒟\left(x^{n-1}\right)$$ for all $x\in ℛ$ and some fixed integer $n\ge 2$, then $𝒟$ is an ($\phi$, $\varphi$)-derivation. Moreover, this result makes it possible to prove that if $ℛ$ admits an additive mappings $𝒟,𝒢:ℛ\to ℛ$ satisfying the relations $$\begin{array}{c}2𝒟\left(x^n\right)=𝒟\left(x^{n-1}\right)\phi \left(x\right)+\varphi \left(x^{n-1}\right)𝒢\left(x\right)+𝒢\left(x\right)\phi \left(x^{n-1}\right)+\varphi \left(x\right)𝒢\left(x^{n-1}\right),\\ 2𝒢\left(x^n\right)=𝒢\left(x^{n-1}\right)\phi \left(x\right)+\varphi \left(x^{n-1}\right)𝒟\left(x\right)+𝒟\left(x\right)\phi \left(x^{n-1}\right)+\varphi \left(x\right)𝒟\left(x^{n-1}\right),\end{array}$$ for all $x\in ℛ$ and some fixed integer $n\ge 2$, then $𝒟$ and $𝒢$ are ($\phi$, $\varphi$)derivations under some torsion restriction. Finally, we apply these purely ring theoretic results to semi-simple Banach algebras.

Let $𝒳$ be a Banach space of dimension $n>1$ and $𝔄\subset ℬ\left(𝒳\right)$ be a standard operator algebra. In the present paper it is shown that if a mapping $d:𝔄\to 𝔄$ (not necessarily linear) satisfies $$d\left(\right[[U,V],W\left]\right)=\left[\right[d\left(U\right),V],W]+\left[\right[U,d\left(V\right)],W]+\left[\right[U,V],d(W\left)\right]$$ for all $U,V,W\in 𝔄$, then $d=\psi +\tau$, where $\psi$ is an additive derivation of $𝔄$ and $\tau :𝔄\to 𝔽I$ vanishes at second commutator $\left[\right[U,V],W]$ for all $U,V,W\in 𝔄$. Moreover, if $d$ is linear and satisfies the above relation, then there exists an operator $S\in 𝔄$ and a linear mapping $\tau$ from $𝔄$ into $𝔽I$ satisfying $\tau \left(\right[[U,V],W\left]\right)=0$ for all $U,V,W\in 𝔄$, such that $d\left(U\right)=SU-US+\tau \left(U\right)$ for all $U\in 𝔄$.

Let $\mathscr{H}$ be an infinite-dimensional complex Hilbert space and $𝔄$ be a standard operator algebra on $\mathscr{H}$ which is closed under the adjoint operation. It is shown that every nonlinear $*$-Lie higher derivation $𝒟={\left\{{\delta }_n\right\}}_{n\in \mathbb{N}}$ of $𝔄$ is automatically an additive higher derivation on $𝔄$. Moreover, $𝒟={\left\{{\delta }_n\right\}}_{n\in \mathbb{N}}$ is an inner $*$-higher derivation.

Let $𝔄=\left(\begin{array}{cc}𝒜& ℳ\\ & ℬ\end{array}\right)$ be the triangular algebra consisting of unital algebras $𝒜$ and $ℬ$ over a commutative ring $R$ with identity $1$ and $ℳ$ be a unital $(𝒜,ℬ)$-bimodule. An additive subgroup $𝔏$ of $𝔄$ is said to be a Lie ideal of $𝔄$ if $[𝔏,𝔄]\subseteq 𝔏$. A non-central square closed Lie ideal $𝔏$ of $𝔄$ is known as an admissible Lie ideal. The main result of the present paper states that under certain restrictions on $𝔄$, every generalized Jordan triple higher derivation of $𝔏$ into $𝔄$ is a generalized higher derivation of $𝔏$ into $𝔄$.