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The Uniform Minimum-Ones 2SAT Problem and its Application to Haplotype Classification

Hans-Joachim BöckenhauerMichal ForišekJán OravecBjörn SteffenKathleen SteinhöfelMonika Steinová — 2010

RAIRO - Theoretical Informatics and Applications

Analyzing genomic data for finding those gene variations which are responsible for hereditary diseases is one of the great challenges in modern bioinformatics. In many living beings (including the human), every gene is present in two copies, inherited from the two parents, the so-called . In this paper, we propose a simple combinatorial model for classifying the set of haplotypes in a population according to their responsibility for a certain genetic disease. This model is based on the minimum-ones...

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