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Influenza del tumore ascite di Ehrlich sulla capacità clonante del fegato fetale

Paolo MocarelliGianni GarottaCarla PortaMaria Luisa VillaEnrico Clerici — 1972

Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti

Female Swiss albino mice were mated with normal males. Liver cells obtained from seventeen-day pregnant mice, either normal or given i.p. 10 Ehrlich ascites carcinoma cells one week earlier, were injected i.v. into lethally x-irradiated recipients. The spleen colonizing capacity of the "tumoral" liver was significantly decreased as compared to that of normal controls. The present data confirm our previous findings on the inhibitory efiect of Ehrlich ascites carcinoma on the colony forming power...

Meccamsmi cellulari della immunodepressione da tumore

Paolo MocarelliMaria Luisa VillaAugusto PessinaGiuseppe BigiEnrico Clerici — 1970

Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti

Adult mice grafted i.p. with Ehrlich ascites-carcinoma cells and then exposed to sublethal X—irradiation developed a significantly smaller number of "endogenous" spleen colonies than X-irradiated controls not grafted with tumor cells. Similar results were obtained when bone marrow cells from tumor bearing mice were injected i.v. into lethally X-irradiated mice, so as to produce "exogenous" spleen colonies. In both experiments, the Ehrlich ascites-carcinoma inoculum necessary to reduce significantly...

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