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Characterization of lung tumor subtypes through gene expression cluster validity assessment

Giorgio ValentiniFrancesca Ruffino — 2006

RAIRO - Theoretical Informatics and Applications

The problem of assessing the reliability of clusters patients identified by clustering algorithms is crucial to estimate the significance of subclasses of diseases detectable at bio-molecular level, and more in general to support bio-medical discovery of patterns in gene expression data. In this paper we present an experimental analysis of the reliability of clusters discovered in lung tumor patients using DNA microarray data. In particular we investigate if subclasses of lung adenocarcinoma...

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