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Inverse sampling and triangular sequential designs to compare a small proportion with a reference value.

Inverse sampling and formal sequential designs may prove useful in reducing the sample size in studies where a small population proportion p is compared with a hypothesized reference proportion p. These methods are applied to the design of a cytogenetic study about chromosomal abnormalities in men with a daughter affected by Turner's syndrome. First it is shown how the calculated sample size for a classical design depends on the parameterization used. Later this sample size is compared with the...

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