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On the optimization of initial conditions for a model parameter estimation

Matonoha, CtiradPapáček, ŠtěpánKindermann, Stefan — 2017

Programs and Algorithms of Numerical Mathematics

The design of an experiment, e.g., the setting of initial conditions, strongly influences the accuracy of the process of determining model parameters from data. The key concept relies on the analysis of the sensitivity of the measured output with respect to the model parameters. Based on this approach we optimize an experimental design factor, the initial condition for an inverse problem of a model parameter estimation. Our approach, although case independent, is illustrated at the FRAP (Fluorescence...

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