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The interplay between stochastic gene switching and certain metronomics therapies.

Krzysztof Puszynski — 2018

Mathematica Applicanda

In this work I present some preliminary results of the exploration of the interplay between stochastic gene switching and certain metronomics therapies. During the research a simple model of gene-mRNA-protein network subjected to the metronomic therapy was investigated. The results show that the stochastic gene switching process, especially the time expected between successive switching plays a significant role in determining the size of the responding cells fraction.

Computational determination of the optimal dose of the cis-platinum to maximize the life time of patients diagnosed with cancer.

Emilia KozłowskaKrzysztof Puszynski — 2019

Mathematica Applicanda

In this work, we present the results of our study over the expected lifetime of the patients diagnosed with relapsed squamous cell lung cancer, which is a subtype of non-small cell lung cancer, treated by cis-platinum. We developed the mathematical model consist of cells sensitive and resistant to cis-platinum. The performed simulations suggest that the best strategy to prolong the patient lifetime after diagnosis is to keep the sensitive cells subpopulation at the constant level instead of killing...

Regulation of p53 by siRNA in radiation treated cells: Simulation studies

Krzysztof PuszyńskiRoman JaksikAndrzej Świerniak — 2012

International Journal of Applied Mathematics and Computer Science

Ionizing radiation activates a large variety of intracellular mechanisms responsible for maintaining appropriate cell functionality or activation of apoptosis which eliminates damaged cells from the population. The mechanism of such induced cellular death is widely used in radiotherapy in order to eliminate cancer cells, although in some cases it is highly limited by increased cellular radio-resistance due to aberrations in molecular regulation mechanisms of malignant cells. Despite the positive...

Single stranded-DNA detection: the role of Wip1 in ATR-dependent pathway

Monika KurpasKatarzyna JonakKrzysztof Puszynski — 2018

Mathematica Applicanda

Single-stranded DNA (ssDNA) areas arise in cells as a result of exposure to stress agents - like UVC - or during repair of DNA double-strand breaks. ATR(ataxia telangiectasia mutated and Rad3-related) is responsible for detecting ssDNA. Recently, it has been shown that one of the most important components of cellular response to the damage is Wip1 phosphatase, which inactivates main elements of DNA damage response (DDR) pathways. We developed a mathematical model of ATR detector system, connected...

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