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On the Mathematical Modelling of Microbial Growth: Some Computational Aspects

Markov, Svetoslav — 2011

Serdica Journal of Computing

We propose a new approach to the mathematical modelling of microbial growth. Our approach differs from familiar Monod type models by considering two phases in the physiological states of the microorganisms and makes use of basic relations from enzyme kinetics. Such an approach may be useful in the modelling and control of biotechnological processes, where microorganisms are used for various biodegradation purposes and are often put under extreme inhibitory conditions. Some computational experiments are...

On the Arithmetic of Errors

Markov, SvetoslavHayes, Nathan — 2010

Serdica Journal of Computing

An approximate number is an ordered pair consisting of a (real) number and an error bound, briefly error, which is a (real) non-negative number. To compute with approximate numbers the arithmetic operations on errors should be well-known. To model computations with errors one should suitably define and study arithmetic operations and order relations over the set of non-negative numbers. In this work we discuss the algebraic properties of non-negative numbers starting from familiar properties of...

On the Approximation of the Generalized Cut Function of Degree p+1 By Smooth Sigmoid Functions

Kyurkchiev, NikolayMarkov, Svetoslav — 2015

Serdica Journal of Computing

We introduce a modification of the familiar cut function by replacing the linear part in its definition by a polynomial of degree p + 1 obtaining thus a sigmoid function called generalized cut function of degree p + 1 (GCFP). We then study the uniform approximation of the (GCFP) by smooth sigmoid functions such as the logistic and the shifted logistic functions. The limiting case of the interval-valued Heaviside step function is also discussed which imposes the use of Hausdorff metric. Numerical examples...

Analysis of Biochemical Mechanisms using Mathematica with Applications

Kyurkchiev, NikolayMarkov, SvetoslavMincheva, Maya — 2016

Serdica Journal of Computing

Biochemical mechanisms with mass action kinetics are usually modeled as systems of ordinary differential equations (ODE) or bipartite graphs. We present a software module for the numerical analysis of ODE models of biochemical mechanisms of chemical species and elementary reactions (BMCSER) within the programming environment of CAS Mathematica. The module BMCSER also visualizes the bipartite graph of biochemical mechanisms. Numerical examples, including a double phosphorylation model, are presented...

Stochastic Arithmetic Theory and Experiments

Alt, RenéLamotte, Jean-LucMarkov, Svetoslav — 2010

Serdica Journal of Computing

Stochastic arithmetic has been developed as a model for exact computing with imprecise data. Stochastic arithmetic provides confidence intervals for the numerical results and can be implemented in any existing numerical software by redefining types of the variables and overloading the operators on them. Here some properties of stochastic arithmetic are further investigated and applied to the computation of inner products and the solution to linear systems. Several numerical experiments are performed showing...

Quasilinear Structures in Stochastic Arithmetic and their Application

Markov, SvetoslavAlt, RenéLamotte, Jean-Luc — 2016

Serdica Journal of Computing

Stochastic arithmetic has been developed as a model for computing with imprecise numbers. In this model, numbers are represented by independent Gaussian variables with known mean value and standard deviation and are called stochastic numbers. The algebraic properties of stochastic numbers have already been studied by several authors. Anyhow, in most life problems the variables are not independent and a direct application of the model to estimate the standard deviation on the result of a numerical...

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