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Single stranded-DNA detection: the role of Wip1 in ATR-dependent pathway

Monika Kurpas;  Katarzyna Jonak;  Krzysztof Puszynski — 2018

Mathematica Applicanda

Single-stranded DNA (ssDNA) areas arise in cells as a result of exposure to stress agents - like UVC - or during repair of DNA double-strand breaks. ATR(ataxia telangiectasia mutated and Rad3-related) is responsible for detecting ssDNA. Recently, it has been shown that one of the most important components of cellular response to the damage is Wip1 phosphatase, which inactivates main elements of DNA damage response (DDR) pathways. We developed a mathematical model of ATR detector system, connected...

Prediction of lung cancer patients’ response to combined chemo-radiotherapy using a personalized hybrid model

Sebastian Wołkowicz;  Krzysztof Fujarewicz;  Monika Kurpas;  Krzysztof Łakomiec;  Jarosław Śmieja;  Rafal Suwiński;  Andrzej Świerniak — 2019

Mathematica Applicanda

The paper presents a novel approach to the prediction of the combined therapy outcome for non-small lung cancer patients. A hybrid model is proposed, consisting of two parts. The first one is a mathematical model of tumor response to therapy, whose parameters are expressed as linear function of data from massspectrometry of patient blood plasma samples. These linear functions constitute thesecond component of the hybrid model. A comparison of clinical and simulation-based survival curves is used...

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