Modeling Morphogenesis and : Towards Quantitative, Predictive, Cell-based Modeling
Cell-based, mathematical models help make sense of morphogenesis— cells organizing into shape and pattern—by capturing cell behavior in simple, purely descriptive models. Cell-based models then predict the tissue-level patterns the cells produce collectively. The first step in a cell-based modeling approach is to isolate sub-processes, the patterning capabilities of one or a few cell types in cell cultures. Cell-based models can then identify the mechanisms responsible for patterning . This review...