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Let $(M,d)$ be a metric space, equipped with a Borel measure $\mu$ satisfying suitable compatibility conditions. An amalgam $A_p^q\left(M\right)$ is a space which looks locally like $L^p\left(M\right)$ but globally like $L^q\left(M\right)$. We consider the case where the measure $\mu \left(B\right(x,\rho )$ of the ball $B(x,\rho )$ with centre $x$ and radius $\rho$ behaves like a polynomial in $\rho$, and consider the mapping properties between amalgams of kernel operators where the kernel $kerK(x,y)$ behaves like $d(x,y{)}^{-a}$ when $d(x,y)\le 1$ and like $d(x,y{)}^{-b}$ when $d(x,y)\ge 1$. As an application, we describe Hardy–Littlewood–Sobolev type regularity theorems...