Vasculogenesis Models Revisited - Measurement of VEGF Diffusion in Matrigel
The circulatory system is one of the first to function during development. The earliest event in the system's development is , whereby vascular progeniter cells form clusters called blood islands, which later fuse to form capillary networks. There exists a very good system that mimics this process. When HUVECs (Human Umbilical Vein Endothelial Cells) are cultured on Matrigel, they spontaneously form a capillary network structure. Two theoretical models have been proposed to explain the pattern formation...