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Human Immunodeficiency Virus Infection : from Biological Observations to Mechanistic Mathematical Modelling

G. BocharovV. ChereshnevI. GainovaS. BazhanB. BachmetyevJ. ArgilaguetJ. MartinezA. Meyerhans — 2012

Mathematical Modelling of Natural Phenomena

HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold and mediated through a range of positive and negative feedback regulations of immune and physiological processes engaged in virus-host interactions. The fundamental questions towards understanding the pathogenesis of HIV infection are now shifting to ‘dynamic’ categories: (i) why is the HIV-immune response equilibrium finally disrupted? (ii)...

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