Nonparametric estimation of the density of the alternative hypothesis in a multiple testing setup. Application to local false discovery rate estimation
In a multiple testing context, we consider a semiparametric mixture model with two components where one component is known and corresponds to the distribution of -values under the null hypothesis and the other component is nonparametric and stands for the distribution under the alternative hypothesis. Motivated by the issue of local false discovery rate estimation, we focus here on the estimation of the nonparametric unknown component in the mixture, relying on a preliminary estimator of the unknown...