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Spatial Dynamics of Contact-Activated Fibrin Clot Formation and in Haemophilia B: Effects of Severity and Ahemphil B Treatment

A. A. TokarevYu. V. KrasotkinaM. V. OvanesovM. A. PanteleevM. A. AzhigirovaV. A. VolpertF. I. AtaullakhanovA. A. Butilin — 2010

Mathematical Modelling of Natural Phenomena

Spatial dynamics of fibrin clot formation in non-stirred system activated by glass surface was studied as a function of FIX activity. Haemophilia B plasma was obtained from untreated patients with different levels of FIX deficiency and from severe haemophilia B patient treated with FIX concentrate (Ahemphil B) during its clearance with half-life t=12 hours. As reported previously (Ataullakhanov et al. Biochim Biophys Acta 1998; 1425: 453-468), clot growth in space showed two distinct phases: activation...

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