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A haplotype analysis is becoming increasingly important in studying complex genetic diseases. Various algorithms and specialized computer software have been developed to statistically estimate haplotype frequencies from marker phenotypes in unrelated individuals. However, currently there are very few empirical reports on the performance of the methods for the recovery of haplotype frequencies. One of the most widely used methods of haplotype reconstruction is the Maximum Likelihood method, employing...
In this paper we study the error rate of RNA synthesis in the look-ahead model for the
random walk of RNA polymerase along DNA during transcription. The model’s central
assumption is the existence of a window of activity in which
ribonucleoside triphosphates (rNTPs) bind reversibly to the template DNA strand before
being hydrolyzed and linked covalently to the nascent RNA chain. An unknown, but
important, integer parameter of this model is the window...
DNA microarrays have been widely used in molecular biology laboratories. The main current application of these devices is the determination of the gene expression level for thousands of genes simultaneously. Here we review a recently introduced physical model for hybridization (i.e. the binding of complementary DNA strands) in Affymetrix arrays and compare it to experimental results. The experimental data follow rather well the microscopic model and the approach offers several advantages compared...
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