Investigation of the Migration/Proliferation Dichotomy and its Impact on Avascular Glioma Invasion

K. Böttger; H. Hatzikirou; A. Chauviere; A. Deutsch

Mathematical Modelling of Natural Phenomena (2012)

  • Volume: 7, Issue: 1, page 105-135
  • ISSN: 0973-5348

Abstract

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Gliomas are highly invasive brain tumors that exhibit high and spatially heterogeneous cell proliferation and motility rates. The interplay of proliferation and migration dynamics plays an important role in the invasion of these malignant tumors. We analyze the regulation of proliferation and migration processes with a lattice-gas cellular automaton (LGCA). We study and characterize the influence of the migration/proliferation dichotomy (also known as the “GO-or-Grow" mechanism) on avascular glioma invasion, in terms of invasion speed and width of the infiltration zone. We show that the invasive behavior of the (macroscopic) tumor colony is a highly complex phenomenon that cannot be extrapolated by the sole knowledge of the (microscopic) individual cell phenotype.

How to cite

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Böttger, K., et al. "Investigation of the Migration/Proliferation Dichotomy and its Impact on Avascular Glioma Invasion." Mathematical Modelling of Natural Phenomena 7.1 (2012): 105-135. <http://eudml.org/doc/222384>.

@article{Böttger2012,
abstract = {Gliomas are highly invasive brain tumors that exhibit high and spatially heterogeneous cell proliferation and motility rates. The interplay of proliferation and migration dynamics plays an important role in the invasion of these malignant tumors. We analyze the regulation of proliferation and migration processes with a lattice-gas cellular automaton (LGCA). We study and characterize the influence of the migration/proliferation dichotomy (also known as the “GO-or-Grow" mechanism) on avascular glioma invasion, in terms of invasion speed and width of the infiltration zone. We show that the invasive behavior of the (macroscopic) tumor colony is a highly complex phenomenon that cannot be extrapolated by the sole knowledge of the (microscopic) individual cell phenotype.},
author = {Böttger, K., Hatzikirou, H., Chauviere, A., Deutsch, A.},
journal = {Mathematical Modelling of Natural Phenomena},
keywords = {avascular glioma invasion; cell migration; proliferation; Go-or-Grow; LGCA; cell migration/proliferation},
language = {eng},
month = {1},
number = {1},
pages = {105-135},
publisher = {EDP Sciences},
title = {Investigation of the Migration/Proliferation Dichotomy and its Impact on Avascular Glioma Invasion},
url = {http://eudml.org/doc/222384},
volume = {7},
year = {2012},
}

TY - JOUR
AU - Böttger, K.
AU - Hatzikirou, H.
AU - Chauviere, A.
AU - Deutsch, A.
TI - Investigation of the Migration/Proliferation Dichotomy and its Impact on Avascular Glioma Invasion
JO - Mathematical Modelling of Natural Phenomena
DA - 2012/1//
PB - EDP Sciences
VL - 7
IS - 1
SP - 105
EP - 135
AB - Gliomas are highly invasive brain tumors that exhibit high and spatially heterogeneous cell proliferation and motility rates. The interplay of proliferation and migration dynamics plays an important role in the invasion of these malignant tumors. We analyze the regulation of proliferation and migration processes with a lattice-gas cellular automaton (LGCA). We study and characterize the influence of the migration/proliferation dichotomy (also known as the “GO-or-Grow" mechanism) on avascular glioma invasion, in terms of invasion speed and width of the infiltration zone. We show that the invasive behavior of the (macroscopic) tumor colony is a highly complex phenomenon that cannot be extrapolated by the sole knowledge of the (microscopic) individual cell phenotype.
LA - eng
KW - avascular glioma invasion; cell migration; proliferation; Go-or-Grow; LGCA; cell migration/proliferation
UR - http://eudml.org/doc/222384
ER -

References

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