Mathematical and numerical modeling of early atherosclerotic lesions***

Vincent Calvez; Jean Gabriel Houot; Nicolas Meunier; Annie Raoult; Gabriela Rusnakova

ESAIM: Proceedings (2010)

  • Volume: 30, page 1-14
  • ISSN: 1270-900X

Abstract

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This article is devoted to the construction of a mathematical model describing the early formation of atherosclerotic lesions. The early stage of atherosclerosis is an inflammatory process that starts with the penetration of low density lipoproteins in the intima and with their oxidation. This phenomenon is closely linked to the local blood flow dynamics. Extending a previous work [5] that was mainly restricted to a one-dimensional setting, we couple a simple lesion growth model relying on the biomolecular process that takes place in the intima with blood flow dynamics and mass transfer. We perform numerical simulations on a two-dimensional geometry taken from [6,7] that mimicks a carotid artery deformed by a perivascular cast and we compare the numerical results with experimental data.

How to cite

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Calvez, Vincent, et al. Bresch, D., et al, eds. " Mathematical and numerical modeling of early atherosclerotic lesions***." ESAIM: Proceedings 30 (2010): 1-14. <http://eudml.org/doc/251257>.

@article{Calvez2010,
abstract = {This article is devoted to the construction of a mathematical model describing the early formation of atherosclerotic lesions. The early stage of atherosclerosis is an inflammatory process that starts with the penetration of low density lipoproteins in the intima and with their oxidation. This phenomenon is closely linked to the local blood flow dynamics. Extending a previous work [5] that was mainly restricted to a one-dimensional setting, we couple a simple lesion growth model relying on the biomolecular process that takes place in the intima with blood flow dynamics and mass transfer. We perform numerical simulations on a two-dimensional geometry taken from [6,7] that mimicks a carotid artery deformed by a perivascular cast and we compare the numerical results with experimental data.},
author = {Calvez, Vincent, Houot, Jean Gabriel, Meunier, Nicolas, Raoult, Annie, Rusnakova, Gabriela},
editor = {Bresch, D., Calvez, V., Grenier, E., Vigneaux, P., Gerbeau, J-F.},
journal = {ESAIM: Proceedings},
language = {eng},
month = {12},
pages = {1-14},
publisher = {EDP Sciences},
title = { Mathematical and numerical modeling of early atherosclerotic lesions***},
url = {http://eudml.org/doc/251257},
volume = {30},
year = {2010},
}

TY - JOUR
AU - Calvez, Vincent
AU - Houot, Jean Gabriel
AU - Meunier, Nicolas
AU - Raoult, Annie
AU - Rusnakova, Gabriela
AU - Bresch, D.
AU - Calvez, V.
AU - Grenier, E.
AU - Vigneaux, P.
AU - Gerbeau, J-F.
TI - Mathematical and numerical modeling of early atherosclerotic lesions***
JO - ESAIM: Proceedings
DA - 2010/12//
PB - EDP Sciences
VL - 30
SP - 1
EP - 14
AB - This article is devoted to the construction of a mathematical model describing the early formation of atherosclerotic lesions. The early stage of atherosclerosis is an inflammatory process that starts with the penetration of low density lipoproteins in the intima and with their oxidation. This phenomenon is closely linked to the local blood flow dynamics. Extending a previous work [5] that was mainly restricted to a one-dimensional setting, we couple a simple lesion growth model relying on the biomolecular process that takes place in the intima with blood flow dynamics and mass transfer. We perform numerical simulations on a two-dimensional geometry taken from [6,7] that mimicks a carotid artery deformed by a perivascular cast and we compare the numerical results with experimental data.
LA - eng
UR - http://eudml.org/doc/251257
ER -

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