Generating Vectors for the Lattice Structures of Tubular and Conical Viral Capsids

Farrah Sadre-Marandi; Jiangguo Liu; Simon Tavener; Chaoping Chen

Molecular Based Mathematical Biology (2014)

  • Volume: 2, Issue: 1
  • ISSN: 2299-3266

Abstract

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Retrovirus capsid is a fullerene-like lattice consisting of capsid protein hexamers and pentamers. Mathematical models for the lattice structure help understand the underlying biological mechanisms in the formation of viral capsids. It is known that viral capsids could be categorized into three major types: icosahedron, tube, and cone. While the model for icosahedral capsids is established and well-received, models for tubular and conical capsids need further investigation. This paper proposes new models for the tubular and conical capsids based on an extension of the Capser-Klug quasi-equivalence theory. In particular, two and three generating vectors are used to characterize respectively the lattice structures of tubular and conical capsids. Comparison with published HIV-1 data demonstrates a good agreement of our modeling results with experimental data.

How to cite

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Farrah Sadre-Marandi, et al. "Generating Vectors for the Lattice Structures of Tubular and Conical Viral Capsids." Molecular Based Mathematical Biology 2.1 (2014): null. <http://eudml.org/doc/268690>.

@article{FarrahSadre2014,
abstract = {Retrovirus capsid is a fullerene-like lattice consisting of capsid protein hexamers and pentamers. Mathematical models for the lattice structure help understand the underlying biological mechanisms in the formation of viral capsids. It is known that viral capsids could be categorized into three major types: icosahedron, tube, and cone. While the model for icosahedral capsids is established and well-received, models for tubular and conical capsids need further investigation. This paper proposes new models for the tubular and conical capsids based on an extension of the Capser-Klug quasi-equivalence theory. In particular, two and three generating vectors are used to characterize respectively the lattice structures of tubular and conical capsids. Comparison with published HIV-1 data demonstrates a good agreement of our modeling results with experimental data.},
author = {Farrah Sadre-Marandi, Jiangguo Liu, Simon Tavener, Chaoping Chen},
journal = {Molecular Based Mathematical Biology},
keywords = {CA protein; capsid; cone; hexamer; HIV-1; icosahedron; pentamer; tube},
language = {eng},
number = {1},
pages = {null},
title = {Generating Vectors for the Lattice Structures of Tubular and Conical Viral Capsids},
url = {http://eudml.org/doc/268690},
volume = {2},
year = {2014},
}

TY - JOUR
AU - Farrah Sadre-Marandi
AU - Jiangguo Liu
AU - Simon Tavener
AU - Chaoping Chen
TI - Generating Vectors for the Lattice Structures of Tubular and Conical Viral Capsids
JO - Molecular Based Mathematical Biology
PY - 2014
VL - 2
IS - 1
SP - null
AB - Retrovirus capsid is a fullerene-like lattice consisting of capsid protein hexamers and pentamers. Mathematical models for the lattice structure help understand the underlying biological mechanisms in the formation of viral capsids. It is known that viral capsids could be categorized into three major types: icosahedron, tube, and cone. While the model for icosahedral capsids is established and well-received, models for tubular and conical capsids need further investigation. This paper proposes new models for the tubular and conical capsids based on an extension of the Capser-Klug quasi-equivalence theory. In particular, two and three generating vectors are used to characterize respectively the lattice structures of tubular and conical capsids. Comparison with published HIV-1 data demonstrates a good agreement of our modeling results with experimental data.
LA - eng
KW - CA protein; capsid; cone; hexamer; HIV-1; icosahedron; pentamer; tube
UR - http://eudml.org/doc/268690
ER -

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