Numerical simulation of surface acoustic wave actuated cell sorting

Thomas Franke; Ronald Hoppe; Christopher Linsenmann; Kidist Zeleke

Open Mathematics (2013)

  • Volume: 11, Issue: 4, page 760-778
  • ISSN: 2391-5455

Abstract

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We consider the mathematical modeling and numerical simulation of high throughput sorting of two different types of biological cells (type I and type II) by a biomedical micro-electro-mechanical system (BioMEMS) whose operating behavior relies on surface acoustic wave (SAW) manipulated fluid flow in a microchannel. The BioMEMS consists of a separation channel with three inflow channels for injection of the carrier fluid and the cells, two outflow channels for separation, and an interdigital transducer (IDT) close to the lateral wall of the separation channel for generation of the SAWs. The cells can be distinguished by fluorescence. The inflow velocities are tuned so that without SAW actuation a cell of type I leaves the device through a designated outflow channel. However, if a cell of type II is detected, the IDT is switched on and the SAWs modify the fluid flow so that the cell leaves the separation channel through the other outflow boundary. The motion of a cell in the carrier fluid is modeled by the Finite Element Immersed Boundary method (FE-IB). Numerical results are presented that illustrate the feasibility of the surface acoustic wave actuated cell sorting approach.

How to cite

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Thomas Franke, et al. "Numerical simulation of surface acoustic wave actuated cell sorting." Open Mathematics 11.4 (2013): 760-778. <http://eudml.org/doc/269560>.

@article{ThomasFranke2013,
abstract = {We consider the mathematical modeling and numerical simulation of high throughput sorting of two different types of biological cells (type I and type II) by a biomedical micro-electro-mechanical system (BioMEMS) whose operating behavior relies on surface acoustic wave (SAW) manipulated fluid flow in a microchannel. The BioMEMS consists of a separation channel with three inflow channels for injection of the carrier fluid and the cells, two outflow channels for separation, and an interdigital transducer (IDT) close to the lateral wall of the separation channel for generation of the SAWs. The cells can be distinguished by fluorescence. The inflow velocities are tuned so that without SAW actuation a cell of type I leaves the device through a designated outflow channel. However, if a cell of type II is detected, the IDT is switched on and the SAWs modify the fluid flow so that the cell leaves the separation channel through the other outflow boundary. The motion of a cell in the carrier fluid is modeled by the Finite Element Immersed Boundary method (FE-IB). Numerical results are presented that illustrate the feasibility of the surface acoustic wave actuated cell sorting approach.},
author = {Thomas Franke, Ronald Hoppe, Christopher Linsenmann, Kidist Zeleke},
journal = {Open Mathematics},
keywords = {Surface acoustic wave actuated cell sorting; Biomedical micro-electro-mechanical system; Finite element immersed boundary method; surface acoustic wave actuated cell sorting; biomedical micro-electro-mechanical system; finite element immersed boundary method},
language = {eng},
number = {4},
pages = {760-778},
title = {Numerical simulation of surface acoustic wave actuated cell sorting},
url = {http://eudml.org/doc/269560},
volume = {11},
year = {2013},
}

TY - JOUR
AU - Thomas Franke
AU - Ronald Hoppe
AU - Christopher Linsenmann
AU - Kidist Zeleke
TI - Numerical simulation of surface acoustic wave actuated cell sorting
JO - Open Mathematics
PY - 2013
VL - 11
IS - 4
SP - 760
EP - 778
AB - We consider the mathematical modeling and numerical simulation of high throughput sorting of two different types of biological cells (type I and type II) by a biomedical micro-electro-mechanical system (BioMEMS) whose operating behavior relies on surface acoustic wave (SAW) manipulated fluid flow in a microchannel. The BioMEMS consists of a separation channel with three inflow channels for injection of the carrier fluid and the cells, two outflow channels for separation, and an interdigital transducer (IDT) close to the lateral wall of the separation channel for generation of the SAWs. The cells can be distinguished by fluorescence. The inflow velocities are tuned so that without SAW actuation a cell of type I leaves the device through a designated outflow channel. However, if a cell of type II is detected, the IDT is switched on and the SAWs modify the fluid flow so that the cell leaves the separation channel through the other outflow boundary. The motion of a cell in the carrier fluid is modeled by the Finite Element Immersed Boundary method (FE-IB). Numerical results are presented that illustrate the feasibility of the surface acoustic wave actuated cell sorting approach.
LA - eng
KW - Surface acoustic wave actuated cell sorting; Biomedical micro-electro-mechanical system; Finite element immersed boundary method; surface acoustic wave actuated cell sorting; biomedical micro-electro-mechanical system; finite element immersed boundary method
UR - http://eudml.org/doc/269560
ER -

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