A selection modelling approach to analysing missing data of liver Cirrhosis patients

Dilip C. Nath, Ramesh K. Vishwakarma, and Atanu Bhattacharjee. "A selection modelling approach to analysing missing data of liver Cirrhosis patients." Biometrical Letters 53.2 (2016): 83-103. <http://eudml.org/doc/287168>.

@article{DilipC2016,
abstract = {Methods for dealing with missing data in clinical trials have received increased attention from the regulators and practitioners in the pharmaceutical industry over the last few years. Consideration of missing data in a study is important as they can lead to substantial biases and have an impact on overall statistical power. This problem may be caused by patients dropping before completion of the study. The new guidelines of the International Conference on Harmonization place great emphasis on the importance of carefully choosing primary analysis methods based on clearly formulated assumptions regarding the missingness mechanism. The reason for dropout or withdrawal would be either related to the trial (e.g. adverse event, death, unpleasant study procedures, lack of improvement) or unrelated to the trial (e.g. moving away, unrelated disease). We applied selection models on liver cirrhosis patient data to analyse the treatment efficiency comparing the surgery of liver cirrhosis patients with consenting for participation HFLPC (Human Fatal Liver Progenitor Cells) infusion with surgery alone. It was found that comparison between treatment conditions when missing values are ignored potentially leads to biased conclusions.},
author = {Dilip C. Nath, Ramesh K. Vishwakarma, Atanu Bhattacharjee},
journal = {Biometrical Letters},
keywords = {selection model; model for end-stage liver disease; missing not at random},
language = {eng},
number = {2},
pages = {83-103},
title = {A selection modelling approach to analysing missing data of liver Cirrhosis patients},
url = {http://eudml.org/doc/287168},
volume = {53},
year = {2016},
}

TY - JOUR
AU - Dilip C. Nath
AU - Ramesh K. Vishwakarma
AU - Atanu Bhattacharjee
TI - A selection modelling approach to analysing missing data of liver Cirrhosis patients
JO - Biometrical Letters
PY - 2016
VL - 53
IS - 2
SP - 83
EP - 103
AB - Methods for dealing with missing data in clinical trials have received increased attention from the regulators and practitioners in the pharmaceutical industry over the last few years. Consideration of missing data in a study is important as they can lead to substantial biases and have an impact on overall statistical power. This problem may be caused by patients dropping before completion of the study. The new guidelines of the International Conference on Harmonization place great emphasis on the importance of carefully choosing primary analysis methods based on clearly formulated assumptions regarding the missingness mechanism. The reason for dropout or withdrawal would be either related to the trial (e.g. adverse event, death, unpleasant study procedures, lack of improvement) or unrelated to the trial (e.g. moving away, unrelated disease). We applied selection models on liver cirrhosis patient data to analyse the treatment efficiency comparing the surgery of liver cirrhosis patients with consenting for participation HFLPC (Human Fatal Liver Progenitor Cells) infusion with surgery alone. It was found that comparison between treatment conditions when missing values are ignored potentially leads to biased conclusions.
LA - eng
KW - selection model; model for end-stage liver disease; missing not at random
UR - http://eudml.org/doc/287168
ER -