Fast optical tracking of diffusion in time-dependent environment of brain extracellular space

Hrabě, Jan

  • Applications of Mathematics 2013, Publisher: Institute of Mathematics AS CR(Prague), page 117-123

Abstract

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An improved version of the Integrative Optical Imaging (IOI) method for diffusion measurements in a geometrically complex environment of the brain extracellular space has been developed. We present a theory for this Fast Optical Tracking Of Diffusion (FOTOD) which incorporates a time-dependent effective diffusion coefficient in homogeneous anisotropic media with time-dependent nonspecific linear clearance. FOTOD can be used to measure rapid changes in extracellular diffusion permeability that occur, e.g., during brain insults. The achievable time resolution is approximately one second, a ten fold improvement compared to the traditional IOI method.

How to cite

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Hrabě, Jan. "Fast optical tracking of diffusion in time-dependent environment of brain extracellular space." Applications of Mathematics 2013. Prague: Institute of Mathematics AS CR, 2013. 117-123. <http://eudml.org/doc/287780>.

@inProceedings{Hrabě2013,
abstract = {An improved version of the Integrative Optical Imaging (IOI) method for diffusion measurements in a geometrically complex environment of the brain extracellular space has been developed. We present a theory for this Fast Optical Tracking Of Diffusion (FOTOD) which incorporates a time-dependent effective diffusion coefficient in homogeneous anisotropic media with time-dependent nonspecific linear clearance. FOTOD can be used to measure rapid changes in extracellular diffusion permeability that occur, e.g., during brain insults. The achievable time resolution is approximately one second, a ten fold improvement compared to the traditional IOI method.},
author = {Hrabě, Jan},
booktitle = {Applications of Mathematics 2013},
keywords = {optical tracking of diffusion; brain extracellular space; diffusion equation; Fourier transform; point spread function},
location = {Prague},
pages = {117-123},
publisher = {Institute of Mathematics AS CR},
title = {Fast optical tracking of diffusion in time-dependent environment of brain extracellular space},
url = {http://eudml.org/doc/287780},
year = {2013},
}

TY - CLSWK
AU - Hrabě, Jan
TI - Fast optical tracking of diffusion in time-dependent environment of brain extracellular space
T2 - Applications of Mathematics 2013
PY - 2013
CY - Prague
PB - Institute of Mathematics AS CR
SP - 117
EP - 123
AB - An improved version of the Integrative Optical Imaging (IOI) method for diffusion measurements in a geometrically complex environment of the brain extracellular space has been developed. We present a theory for this Fast Optical Tracking Of Diffusion (FOTOD) which incorporates a time-dependent effective diffusion coefficient in homogeneous anisotropic media with time-dependent nonspecific linear clearance. FOTOD can be used to measure rapid changes in extracellular diffusion permeability that occur, e.g., during brain insults. The achievable time resolution is approximately one second, a ten fold improvement compared to the traditional IOI method.
KW - optical tracking of diffusion; brain extracellular space; diffusion equation; Fourier transform; point spread function
UR - http://eudml.org/doc/287780
ER -

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