Simultaneous testing procedures of many null hypotheses and their applications in the DNA microarrays analysis

Marcin Dudziński; Konrad Furmańczyk

Mathematica Applicanda (2007)

  • Volume: 35, Issue: 49/08
  • ISSN: 1730-2668

Abstract

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In our paper, we consider different approaches to the problem of simultaneous testing of many null hypotheses. In this context, we discuss the single-step, the step-down and the step-up procedures of multiple testing. In particular, we are concerned with their properties and applications in the control of the error rates, such as:FW ER, k-FWER, FDP, FDR, pFDR. The mentioned procedures are intensively used in the DNA microarrays analysis, which enables the monitoring of expression levels of many genes simultaneously and is widely applied in recent medical diagnostics, treatment and research.

How to cite

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Marcin Dudziński, and Konrad Furmańczyk. "Simultaneous testing procedures of many null hypotheses and their applications in the DNA microarrays analysis." Mathematica Applicanda 35.49/08 (2007): null. <http://eudml.org/doc/292932>.

@article{MarcinDudziński2007,
abstract = {In our paper, we consider different approaches to the problem of simultaneous testing of many null hypotheses. In this context, we discuss the single-step, the step-down and the step-up procedures of multiple testing. In particular, we are concerned with their properties and applications in the control of the error rates, such as:FW ER, k-FWER, FDP, FDR, pFDR. The mentioned procedures are intensively used in the DNA microarrays analysis, which enables the monitoring of expression levels of many genes simultaneously and is widely applied in recent medical diagnostics, treatment and research.},
author = {Marcin Dudziński, Konrad Furmańczyk},
journal = {Mathematica Applicanda},
keywords = {Multiple hypothesis testing procedures, Familywise error rate, False discovery proportion, False discovery rate, p-values, q-values, DNA microarrays},
language = {eng},
number = {49/08},
pages = {null},
title = {Simultaneous testing procedures of many null hypotheses and their applications in the DNA microarrays analysis},
url = {http://eudml.org/doc/292932},
volume = {35},
year = {2007},
}

TY - JOUR
AU - Marcin Dudziński
AU - Konrad Furmańczyk
TI - Simultaneous testing procedures of many null hypotheses and their applications in the DNA microarrays analysis
JO - Mathematica Applicanda
PY - 2007
VL - 35
IS - 49/08
SP - null
AB - In our paper, we consider different approaches to the problem of simultaneous testing of many null hypotheses. In this context, we discuss the single-step, the step-down and the step-up procedures of multiple testing. In particular, we are concerned with their properties and applications in the control of the error rates, such as:FW ER, k-FWER, FDP, FDR, pFDR. The mentioned procedures are intensively used in the DNA microarrays analysis, which enables the monitoring of expression levels of many genes simultaneously and is widely applied in recent medical diagnostics, treatment and research.
LA - eng
KW - Multiple hypothesis testing procedures, Familywise error rate, False discovery proportion, False discovery rate, p-values, q-values, DNA microarrays
UR - http://eudml.org/doc/292932
ER -

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