Sensitivity Analysis Aimed at Finding Potential Molecular Drug Targets

Jaroslaw Smieja; Małgorzata Kardyńska; Marta Pudlo

Mathematica Applicanda (2019)

  • Volume: 47, Issue: 2
  • ISSN: 1730-2668

Abstract

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Sensitivity analysis has become one of the standard tools in analysis of models of intracellular processes. Various methods have been proposed, developed for either local or global sensitivity of systems under investigation. In this work, we propose a method that may be used to find potential molecular drug targets, taking into account heterogeneity of population of cells with respect to their responses to a particular drug agent.

How to cite

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Jaroslaw Smieja, Małgorzata Kardyńska, and Marta Pudlo. "Sensitivity Analysis Aimed at Finding Potential Molecular Drug Targets." Mathematica Applicanda 47.2 (2019): null. <http://eudml.org/doc/295498>.

@article{JaroslawSmieja2019,
abstract = {Sensitivity analysis has become one of the standard tools in analysis of models of intracellular processes. Various methods have been proposed, developed for either local or global sensitivity of systems under investigation. In this work, we propose a method that may be used to find potential molecular drug targets, taking into account heterogeneity of population of cells with respect to their responses to a particular drug agent.},
author = {Jaroslaw Smieja, Małgorzata Kardyńska, Marta Pudlo},
journal = {Mathematica Applicanda},
keywords = {sensitivity analysis, signaling pathways, molecular drug targets},
language = {eng},
number = {2},
pages = {null},
title = {Sensitivity Analysis Aimed at Finding Potential Molecular Drug Targets},
url = {http://eudml.org/doc/295498},
volume = {47},
year = {2019},
}

TY - JOUR
AU - Jaroslaw Smieja
AU - Małgorzata Kardyńska
AU - Marta Pudlo
TI - Sensitivity Analysis Aimed at Finding Potential Molecular Drug Targets
JO - Mathematica Applicanda
PY - 2019
VL - 47
IS - 2
SP - null
AB - Sensitivity analysis has become one of the standard tools in analysis of models of intracellular processes. Various methods have been proposed, developed for either local or global sensitivity of systems under investigation. In this work, we propose a method that may be used to find potential molecular drug targets, taking into account heterogeneity of population of cells with respect to their responses to a particular drug agent.
LA - eng
KW - sensitivity analysis, signaling pathways, molecular drug targets
UR - http://eudml.org/doc/295498
ER -

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