A sparse dynamic programming algorithm for alignment with non-overlapping inversions

Alair Pereira do Lago; Ilya Muchnik; Casimir Kulikowski

RAIRO - Theoretical Informatics and Applications (2010)

  • Volume: 39, Issue: 1, page 175-189
  • ISSN: 0988-3754

Abstract

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Alignment of sequences is widely used for biological sequence comparisons, and only biological events like mutations, insertions and deletions are considered. Other biological events like inversions are not automatically detected by the usual alignment algorithms, thus some alternative approaches have been tried in order to include inversions or other kinds of rearrangements. Despite many important results in the last decade, the complexity of the problem of alignment with inversions is still unknown. In 1992, Schöniger and Waterman proposed the simplification hypothesis that the inversions do not overlap. They also presented an O(n6) exact solution for the alignment with non-overlapping inversions problem and introduced a heuristic for it that brings the average case complexity down. (In this work, n is the maximal length of both sequences that are aligned.) The present paper gives two exact algorithms for the simplified problem. We give a quite simple dynamic program with O(n4)-time and O(n2)-space complexity for alignments with non-overlapping inversions and exhibit a sparse and exact implementation version of this procedure that uses much less resources for some applications with real data.

How to cite

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Alair Pereira do Lago, Muchnik, Ilya, and Kulikowski, Casimir. "A sparse dynamic programming algorithm for alignment with non-overlapping inversions." RAIRO - Theoretical Informatics and Applications 39.1 (2010): 175-189. <http://eudml.org/doc/92754>.

@article{AlairPereiradoLago2010,
abstract = { Alignment of sequences is widely used for biological sequence comparisons, and only biological events like mutations, insertions and deletions are considered. Other biological events like inversions are not automatically detected by the usual alignment algorithms, thus some alternative approaches have been tried in order to include inversions or other kinds of rearrangements. Despite many important results in the last decade, the complexity of the problem of alignment with inversions is still unknown. In 1992, Schöniger and Waterman proposed the simplification hypothesis that the inversions do not overlap. They also presented an O(n6) exact solution for the alignment with non-overlapping inversions problem and introduced a heuristic for it that brings the average case complexity down. (In this work, n is the maximal length of both sequences that are aligned.) The present paper gives two exact algorithms for the simplified problem. We give a quite simple dynamic program with O(n4)-time and O(n2)-space complexity for alignments with non-overlapping inversions and exhibit a sparse and exact implementation version of this procedure that uses much less resources for some applications with real data. },
author = {Alair Pereira do Lago, Muchnik, Ilya, Kulikowski, Casimir},
journal = {RAIRO - Theoretical Informatics and Applications},
language = {eng},
month = {3},
number = {1},
pages = {175-189},
publisher = {EDP Sciences},
title = {A sparse dynamic programming algorithm for alignment with non-overlapping inversions},
url = {http://eudml.org/doc/92754},
volume = {39},
year = {2010},
}

TY - JOUR
AU - Alair Pereira do Lago
AU - Muchnik, Ilya
AU - Kulikowski, Casimir
TI - A sparse dynamic programming algorithm for alignment with non-overlapping inversions
JO - RAIRO - Theoretical Informatics and Applications
DA - 2010/3//
PB - EDP Sciences
VL - 39
IS - 1
SP - 175
EP - 189
AB - Alignment of sequences is widely used for biological sequence comparisons, and only biological events like mutations, insertions and deletions are considered. Other biological events like inversions are not automatically detected by the usual alignment algorithms, thus some alternative approaches have been tried in order to include inversions or other kinds of rearrangements. Despite many important results in the last decade, the complexity of the problem of alignment with inversions is still unknown. In 1992, Schöniger and Waterman proposed the simplification hypothesis that the inversions do not overlap. They also presented an O(n6) exact solution for the alignment with non-overlapping inversions problem and introduced a heuristic for it that brings the average case complexity down. (In this work, n is the maximal length of both sequences that are aligned.) The present paper gives two exact algorithms for the simplified problem. We give a quite simple dynamic program with O(n4)-time and O(n2)-space complexity for alignments with non-overlapping inversions and exhibit a sparse and exact implementation version of this procedure that uses much less resources for some applications with real data.
LA - eng
UR - http://eudml.org/doc/92754
ER -

References

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