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Since cancer is a complex phenomenon that incorporates events occurring on different
length and time scales, therefore multiscale models are needed if we hope to adequately address
cancer specific questions. In this paper we present three different multiscale individual-cell-based
models, each motivated by cancer-related problems emerging from each of the spatial scales: extracellular,
cellular or subcellular, but also incorporating relevant information from other levels.
We apply these hybrid...
Over the past decade or so, there have been a large number of modelling approaches aimed
at elucidating the most important mechanisms affecting the formation of new capillaries
from parent blood vessels — a process known as angiogenesis. Most studies have focussed
upon the way in which capillary sprouts are initiated and migrate in response to
diffusible chemical stimuli supplied by hypoxic stromal cells and leukocytes in the
contexts of solid tumour...
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