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Global well-posedness for the Klein-Gordon-Schrödinger system with generalized higher order coupling, which is a system of PDEs in two variables arising from quantum physics, is proven. It is shown that the system is globally well-posed in $(u,n)\in L^2\times L^2$ under some conditions on the nonlinearity (the coupling term), by using the $L^2$ conservation law for $u$ and controlling the growth of $n$ via the estimates in the local theory. In particular, this extends the well-posedness results for such a system in Miao, Xu (2007)...