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Relative dielectric constants and selectivity ratios in open ionic channels

Bob EisenbergWeishi Liu — 2017

Molecular Based Mathematical Biology

We investigate the effects of the relative dielectric coefficient on ionic flows in open ion channels, using mathematical analysis of reasonably general Poisson-Nernst-Planck type models that can include the finite sizes of ions. The value of the relative dielectric coefficient is of course a crucial parameter for ionic behavior in general. Using the powerful theory of singularly perturbed problems in applied mathematics, we show that some properties of open channels are quite insensitive to variation...

Dynamics of Current, Charge and Mass

Bob EisenbergXavier OriolsDavid Ferry — 2017

Molecular Based Mathematical Biology

Electricity plays a special role in our lives and life. The dynamics of electrons allow light to flow through a vacuum. The equations of electron dynamics are nearly exact and apply from nuclear particles to stars. These Maxwell equations include a special term, the displacement current (of a vacuum). The displacement current allows electrical signals to propagate through space. Displacement current guarantees that current is exactly conserved from inside atoms to between stars, as long as current...

Poisson-Fermi Formulation of Nonlocal Electrostatics in Electrolyte Solutions

Jinn-Liang LiuDexuan XieBob Eisenberg — 2017

Molecular Based Mathematical Biology

We present a nonlocal electrostatic formulation of nonuniform ions and water molecules with interstitial voids that uses a Fermi-like distribution to account for steric and correlation efects in electrolyte solutions. The formulation is based on the volume exclusion of hard spheres leading to a steric potential and Maxwell’s displacement field with Yukawa-type interactions resulting in a nonlocal electric potential. The classical Poisson-Boltzmann model fails to describe steric and correlation effects...

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