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We investigate weighted norm inequalities for the commutator of a fractional integral operator and multiplication by a function. In particular, we show that, for $\mu ,\lambda \in A_{p,q}$ and α/n + 1/q = 1/p, the norm $\left|\right|[b,I_{\alpha }]:L^p\left({\mu }^p\right)\to L^q\left({\lambda }^q\right)\left|\right|$ is equivalent to the norm of b in the weighted BMO space BMO(ν), where $\nu =\mu {\lambda }^{-1}$. This work extends some of the results on this topic existing in the literature, and continues a line of investigation which was initiated by Bloom in 1985 and was recently developed further by the first author, Lacey, and Wick.