The NF-κ B network as an example of a regulatory network with a positive and negative feedback loop
The family of transcription factors NF-κB plays a crucial role in immune response regulation, cell proliferation and cell survival; therefore, deregulated NF-κB activation results in severe health problems. However, its elaborate regulatory network is not yet fully understood. In this paper, we propose and analyze modifications of a mathematical model of the regulatory network that considers the positive feedback between NF-κB and cytokines and the negative feedback between NF-κBand its inhibitors....