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Sufficient conditions for the problem $$\frac{{\partial }^{2}u}{\partial x\partial y}=P_0(x,y)u+P_1(x,y)\frac{\partial u}{\partial x}+P_2(x,y)\frac{\partial u}{\partial y}+q(x,y),u(x+{\omega }_1,y)=u(x,y),u(x,y+{\omega }_2)=u(x,y)$$ to have the Fredholm property and to be uniquely solvable are established, where ${\omega }_1$ and ${\omega }_2$ are positive constants and $P_j:R^2\to R^{n\times n}$ $(j=0,1,2)$ and $q:R^2\to R^n$ are continuous matrix and vector functions periodic in $x$ and $y$.