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Properties of a singular value decomposition based dynamical model of gene expression data

Krzysztof Simek — 2003

International Journal of Applied Mathematics and Computer Science

Recently, data on multiple gene expression at sequential time points were analyzed using the Singular Value Decomposition (SVD) as a means to capture dominant trends, called characteristic modes, followed by the fitting of a linear discrete-time dynamical system in which the expression values at a given time point are linear combinations of the values at a previous time point. We attempt to address several aspects of the method. To obtain the model, we formulate a nonlinear optimization problem...

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