On distributed parameter control systems in the abnormal case and in the case of nonoperator equality constraints.
The extremum principle for problems of optimal control with mixed constraints
Singular controls and chattering arcs in optimal control problems arising in biomedicine
Optimal control for a class of compartmental models in cancer chemotherapy
We consider a general class of mathematical models P for cancer chemotherapy described as optimal control problems over a fixed horizon with dynamics given by a bilinear system and an objective which is linear in the control. Several two- and three-compartment models considered earlier fall into this class. While a killing agent which is active during cell division constitutes the only control considered in the two-compartment model, Model A, also two three-compartment models, Models B and C, are...
Optimal solutions for a model of tumor anti-angiogenesis with a penalty on the cost of treatment
The scheduling of angiogenic inhibitors to control a vascularized tumor is analyzed as an optimal control problem for a mathematical model that was developed and biologically validated by Hahnfeldt et al. [Cancer Res. 59 (1999)]. Two formulations of the problem are considered. In the first one the primary tumor volume is minimized for a given amount of angiogenic inhibitors to be administered, while a balance between tumor reduction and the total amount of angiogenic inhibitors given is minimized...
An optimal control approach to cancer treatment under immunological activity
Mathematical models for cancer treatment that include immunological activity are considered as an optimal control problem with an objective that is motivated by a separatrix of the uncontrolled system. For various growth models on the cancer cells the existence and optimality of singular controls is investigated. For a Gompertzian growth function a synthesis of controls that move the state into the region of attraction of a benign equilibrium point is developed.
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