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A computational framework for testing the effects of cytotoxic molecules, specific to a
given phase of the cell cycle, and vascular disrupting agents (VDAs) is presented. The
model is based on a cellular automaton to describe tumour cell states transitions from
proliferation to death. It is coupled with a model describing the tumour vasculature and
its adaptation to the blood rheological constraints when alterations are induced by VDAs
treatment....
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