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Persistent Homology Analysis of RNA

Adane L. MamuyeMatteo RuccoLuca TeseiEmanuela Merelli — 2016

Molecular Based Mathematical Biology

Topological data analysis has been recently used to extract meaningful information frombiomolecules. Here we introduce the application of persistent homology, a topological data analysis tool, for computing persistent features (loops) of the RNA folding space. The scaffold of the RNA folding space is a complex graph from which the global features are extracted by completing the graph to a simplicial complex via the notion of clique and Vietoris-Rips complexes. The resulting simplicial complexes...

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