One of the most intriguing questions in life science is how living organisms develop and maintain their predominant form and shape via the cascade of the processes of differentiation starting from the single cell. Mathematical modeling of these developmental processes could be a very important tool to properly describe the complex processes of evolution and geometry of morphogenesis in time and space. Here, we summarize the most important biological knowledge on plant development, exploring the...
Recent discovery of cancer stem cells in tumorigenic tissues has raised many questions
about their nature, origin, function and their behavior in cell culture. Most of current
experiments reporting a dynamics of cancer stem cell populations in culture show the
eventual stability of the percentages of these cell populations in the whole population of
cancer cells, independently of the starting conditions. In this paper we propose a
mathematical model...
Many cancer-associated genes and pathways remain to be identified in order to clarify the
molecular mechanisms underlying cancer progression. In this area, genome-wide
loss-of-function screens appear to be powerful biological tools, allowing the accumulation
of large amounts of data. However, this approach currently lacks analytical tools to
exploit the data with maximum efficiency, for which systems biology methods analyzing
complex cellular networks...
Download Results (CSV)