Analysis of a Mathematical Model for the Molecular Mechanism of Fate Decision in Mammary Stem Cells
Recently, adult stem cells have become a focus of intensive biomedical research, but the complex regulation that allows a small population of stem cells to replenish depleted tissues is still unknown. It has been suggested that specific tissue structures delimit the spaces where stem cells undergo unlimited proliferation (). In contrast, mathematical analysis suggests that a feedback control of stem cells on their own proliferation and differentiation (denoted ) suffices for preserving homeostasis...