Recently, adult stem cells have become a focus of intensive biomedical research, but the
complex regulation that allows a small population of stem cells to replenish depleted tissues is still
unknown. It has been suggested that specific tissue structures delimit the spaces where stem cells
undergo unlimited proliferation (). In contrast, mathematical analysis suggests that
a feedback control of stem cells on their own proliferation and differentiation (denoted ) suffices for preserving homeostasis...
Despite recent advances, treatment of patients with aggressive Non-Hodgkin's
lymphoma (NHL) has yet to be optimally designed. Notwithstanding the contribution of
molecular treatments, intensification of chemotherapeutic regimens may still be beneficial.
Hoping to aid in the design of intensified chemotherapy, we put forward a mathematical
and computational model that analyses the effect of Doxorubicin on NHL over a wide
range of patho-physiological conditions. The model represents tumour growth...
Neutropenia is a significant dose-limiting toxicity of cancer
chemotherapy, especially in dose-intensified regimens. It is
widely treated by injections of Granulocyte Colony-Stimulating
Factor (G-CSF). However, optimal schedules of G-CSF administration
are still not determined. In order to aid in identifying more
efficacious and less neutropenic treatment protocols, we studied a
detailed physiologically-based computer model of granulopoiesis,
as affected by different treatment schedules of doxorubicin...
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