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A metacyclic group $H$ can be presented as $\langle \alpha ,\beta :{\alpha }^n=1$, ${\beta }^m={\alpha }^t$, $\beta \alpha {\beta }^{-1}={\alpha }^r\rangle$ for some $n$, $m$, $t$, $r$. Each endomorphism $\sigma$ of $H$ is determined by $\sigma \left(\alpha \right)={\alpha }^{x_1}{\beta }^{y_1}$, $\sigma \left(\beta \right)={\alpha }^{x_2}{\beta }^{y_2}$ for some integers $x_1$, $x_2$, $y_1$, $y_2$. We give sufficient and necessary conditions on $x_1$, $x_2$, $y_1$, $y_2$ for $\sigma$ to be an automorphism.