Displaying similar documents to “Dynamics of the tumor-immune system competition - the effect of time delay”

Immunotherapy with interleukin-2: A study based on mathematical modeling

Sandip Banerjee (2008)

International Journal of Applied Mathematics and Computer Science

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The role of interleukin-2 (IL-2) in tumor dynamics is illustrated through mathematical modeling, using delay differential equations with a discrete time delay (a modified version of the Kirshner-Panetta model). Theoretical analysis gives an expression for the discrete time delay and the length of the time delay to preserve stability. Numerical analysis shows that interleukin-2 alone can cause the tumor cell population to regress.

A mathematical model of HIV-1 infection including the saturation effect of healthy cell proliferation

Mahiéddine Kouche, Bedr'eddine Ainseba (2010)

International Journal of Applied Mathematics and Computer Science

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In this paper we derive a model describing the dynamics of HIV-1 infection in tissue culture where the infection spreads directly from infected cells to healthy cells trough cell-to-cell contact. We assume that the infection rate between healthy and infected cells is a saturating function of cell concentration. Our analysis shows that if the basic reproduction number does not exceed unity then infected cells are cleared and the disease dies out. Otherwise, the infection is persistent...

Model of AIDS-related tumour with time delay

Marek Bodnar, Urszula Foryś, Zuzanna Szymańska (2009)

Applicationes Mathematicae

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We present and compare two simple models of immune system and cancer cell interactions. The first model reflects simple cancer disease progression and serves as our "control" case. The second describes the progression of a cancer disease in the case of a patient infected with the HIV-1 virus.

Analysis of immunotherapy models in the context of cancer dynamics

Zuzanna Szymańska (2003)

International Journal of Applied Mathematics and Computer Science

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A basic mathematical model of the immune response when cancer cells are recognized is proposed. The model consists of six ordinary differential equations. It is extended by taking into account two types of immunotherapy: active immunotherapy and adoptive immunotherapy. An analysis of the corresponding models is made to answer the question which of the presented methods of immunotherapy is better. The analysis is completed by numerical simulations which show that the method of adoptive...