Displaying similar documents to “Singular controls and chattering arcs in optimal control problems arising in biomedicine”

Optimal control from inoculation on a continuous microalgae culture

Jorge Antonio Torres-Muñoz, Irandi Gutierrez-Carmona, Alma Rosa Dominguez-Bocanegra (2016)

Kybernetika

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The present work is centred on the problem of biomass productivity optimization of a culture of microalgae Spirulina maxima. The mathematical tools consisted of necessary and sufficient conditions for optimal control coming from the celebrated Pontryagin's Maximum Principle (PMP) as well as the Bellman's Principle of Optimality, respectively. It is shown that the optimal dilution rate turns to be a bang-singular-bang control. It turns out that, the experimental results are in accordance...

Optimal solutions for a model of tumor anti-angiogenesis with a penalty on the cost of treatment

Urszula Ledzewicz, Vignon Oussa, Heinz Schättler (2009)

Applicationes Mathematicae

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The scheduling of angiogenic inhibitors to control a vascularized tumor is analyzed as an optimal control problem for a mathematical model that was developed and biologically validated by Hahnfeldt et al. [Cancer Res. 59 (1999)]. Two formulations of the problem are considered. In the first one the primary tumor volume is minimized for a given amount of angiogenic inhibitors to be administered, while a balance between tumor reduction and the total amount of angiogenic inhibitors given...

Time minimal control of batch reactors

B. Bonnard, G. Launay (2010)

ESAIM: Control, Optimisation and Calculus of Variations

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In this article we consider a control system modelling a batch reactor in which three species X, X, X are reacting according to the scheme X → X → X, each reaction being irreversible. The control is the temperature T of the reactions or the derivative of this temperature with respect to time. The terminal constraint is to obtain a given concentration of the product X2 at the end of the batch. The objective of our study is to introduce and to apply all the mathematical tools to compute...

An optimal control approach to cancer treatment under immunological activity

Urszula Ledzewicz, Mohammad Naghnaeian, Heinz Schättler (2011)

Applicationes Mathematicae

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Mathematical models for cancer treatment that include immunological activity are considered as an optimal control problem with an objective that is motivated by a separatrix of the uncontrolled system. For various growth models on the cancer cells the existence and optimality of singular controls is investigated. For a Gompertzian growth function a synthesis of controls that move the state into the region of attraction of a benign equilibrium point is developed.

A simple trolley-like model in the presence of a nonlinear friction and a bounded fuel expenditure

Andrei Dmitruk, Ivan Samylovskiy (2013)

Discussiones Mathematicae, Differential Inclusions, Control and Optimization

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We consider a problem of maximization of the distance traveled by a material point in the presence of a nonlinear friction under a bounded thrust and fuel expenditure. Using the maximum principle we obtain the form of optimal control and establish conditions under which it contains a singular subarc. This problem seems to be the simplest one having a mechanical sense in which singular subarcs appear in a nontrivial way.