Displaying similar documents to “A Spatial Model of Tumor Growth with Cell Age, Cell Size, and Mutation of Cell Phenotypes”

Individual Cell-Based Model for In-Vitro Mesothelial Invasion of Ovarian Cancer

C. Giverso, M. Scianna, L. Preziosi, N. Lo Buono, A. Funaro (2010)

Mathematical Modelling of Natural Phenomena

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In vitro transmesothelial migration assays of ovarian cancer cells, isolated or aggregated in multicellular spheroids, are reproduced deducing suitable Cellular Potts Models (CPM). We show that the simulations are in good agreement with the experimental evidence and that the overall process is regulated by the activity of matrix metalloproteinases (MMPs) and by the interplay of the adhesive properties of the cells with the extracellular...