V. Vainstein,
Y. Ginosar,
M. Shoham,
A. Ianovski,
A. Rabinovich,
Y. Kogan,
V. Selitser,
Z. Agur
(2010)
Neutropenia is a significant dose-limiting toxicity of cancer
chemotherapy, especially in dose-intensified regimens. It is
widely treated by injections of Granulocyte Colony-Stimulating
Factor (G-CSF). However, optimal schedules of G-CSF administration
are still not determined. In order to aid in identifying more
efficacious and less neutropenic treatment protocols, we studied a
detailed physiologically-based computer model of granulopoiesis,
as affected by different treatment schedules...