Displaying similar documents to “Free Boundary Problems Associated with Multiscale Tumor Models”

Free boundary problems arising in tumor models

Avner Friedman (2004)

Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti Lincei. Matematica e Applicazioni

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We consider several simple models of tumor growth, described by systems of PDEs, and describe results on existence of solutions and on their asymptotic behavior. The boundary of the tumor region is a free boundary. In §1 the model assumes three types of cells, proliferating, quiescent and necrotic, and the corresponding PDE system consists of elliptic, parabolic and hyperbolic equations. The model in §2 assumes that the tumor has only proliferating cells. Finally in §3 we consider a...

ATP Production and Necrosis Formation in a Tumour Spheroid Model

A. Bertuzzi, A. Fasano, A. Gandolfi, C. Sinisgalli (2010)

Mathematical Modelling of Natural Phenomena

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Mathematical models of tumour spheroids, proposed since the early seventies, have been generally formulated in terms of a single diffusive nutrient which is critical for cell replication and cell viability. Only recently, attempts have been made to incorporate in the models the cell energy metabolism, by considering the interplay between glucose, oxygen and lactate (or pH). By assuming glucose and lactate as the only fuel substrates, we propose a simple model for the cell ATP production...

Cancer as Multifaceted Disease

A. Friedman (2012)

Mathematical Modelling of Natural Phenomena

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Cancer has recently overtaken heart disease as the world’s biggest killer. Cancer is initiated by gene mutations that result in local proliferation of abnormal cells and their migration to other parts of the human body, a process called metastasis. The metastasized cancer cells then interfere with the normal functions of the body, eventually leading to death. There are two hundred types of cancer, classified by their point of origin. Most of ...