Displaying similar documents to “A mathematical tumor model with immune resistance and drug therapy: An optimal control approach.”

A Mathematical Model of Cancer Stem Cell Lineage Population Dynamics with Mutation Accumulation and Telomere Length Hierarchies

G. Kapitanov (2012)

Mathematical Modelling of Natural Phenomena

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There is evidence that cancer develops when cells acquire a sequence of mutations that alter normal cell characteristics. This sequence determines a hierarchy among the cells, based on how many more mutations they need to accumulate in order to become cancerous. When cells divide, they exhibit telomere loss and differentiate, which defines another cell hierarchy, on top of which is the stem cell. We propose a mutation-generation model, ...

Mathematical modeling of the competition between acquired immunity and cancer

Mikhail Kolev (2003)

International Journal of Applied Mathematics and Computer Science

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In this paper we propose and analyse a model of the competition between cancer and the acquired immune system. The model is a system of integro-differential bilinear equations. The role of the humoral response is analyzed. The simulations are related to the immunotherapy of tumors with antibodies.

Analysis of immunotherapy models in the context of cancer dynamics

Zuzanna Szymańska (2003)

International Journal of Applied Mathematics and Computer Science

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A basic mathematical model of the immune response when cancer cells are recognized is proposed. The model consists of six ordinary differential equations. It is extended by taking into account two types of immunotherapy: active immunotherapy and adoptive immunotherapy. An analysis of the corresponding models is made to answer the question which of the presented methods of immunotherapy is better. The analysis is completed by numerical simulations which show that the method of adoptive...