Displaying similar documents to “The role of cell motility in metastatic cell dominance phenomenon: Analysis by a mathematical model.”

The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor Radioresponse

H. Enderling, D. Park, L. Hlatky, P. Hahnfeldt (2009)

Mathematical Modelling of Natural Phenomena

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Tumor growth and progression is a complex phenomenon dependent on the interaction of multiple intrinsic and extrinsic factors. Necessary for tumor development is a small subpopulation of potent cells, so-called cancer stem cells, that can undergo an unlimited number of cell divisions and which are proposed to divide symmetrically with a small probability to produce more cancer stem cells. We show that the majority of cells in a tumor must indeed be non-stem cancer cells with limited...