The role of cell motility in metastatic cell dominance phenomenon: Analysis by a mathematical model.
Kolobov, A.V., Polezhaev, A.A., Solyanik, G.I. (2000)
Journal of Theoretical Medicine
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Kolobov, A.V., Polezhaev, A.A., Solyanik, G.I. (2000)
Journal of Theoretical Medicine
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Byrne, H.M., Chaplain, M.A.J. (1998)
Journal of Theoretical Medicine
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Anderson, A.R.A., Chaplain, M.A.J., Newman, E.L., Steele, R.J.C., Thompson, A.M. (2000)
Journal of Theoretical Medicine
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Gaffney, Eamonn A., Maini, Philip K., Sherratt, Jonathan A., Dale, Paul D. (1997)
Journal of Theoretical Medicine
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H. Enderling, D. Park, L. Hlatky, P. Hahnfeldt (2009)
Mathematical Modelling of Natural Phenomena
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Tumor growth and progression is a complex phenomenon dependent on the interaction of multiple intrinsic and extrinsic factors. Necessary for tumor development is a small subpopulation of potent cells, so-called cancer stem cells, that can undergo an unlimited number of cell divisions and which are proposed to divide symmetrically with a small probability to produce more cancer stem cells. We show that the majority of cells in a tumor must indeed be non-stem cancer cells with limited...